Membranous nephropathy ( MN ) is a renal disease with distinct pathologic features of normocellular glomerular wall thickening and subepitthelial electron dense deposits. MN is a common cause of nephrotic syndrome ( NS ) in adult, but this occurs infrequently in children. Idiopathic MN, a form of MN without any associated systemic diseases used to be uncommon in korean children in whom hepatitis B virus ( HBV ) infection was endemic and HBV-associated MN ( HBV-MN) was the major cause of childhood MN. Moreover, since the introduction of the HBV vaccanation in children in 1985 the prevalence infection and of HBV-MN have been reduced remarkably. Idiophatic MN in still rare, but it now represents the major subset of childhood MN in korea. however, because of its rarity, its clinical course and apropriate treatment are relatively unknown. In adults, several controlled studies have recomended that immunosuppressive agents be administered to patients with NS or presistent nephrotic range proteinuria, although debate remains over the efficacy of the imunosuppressive treatment. moreover in children, the efficacies of imunosuppressive medication have not yet been verified.
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